Hexafluorobenzene: A powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction

Alessandra Lattanzi, Claudia De Fusco, Alessio Russo, Albert Poater, Luigi Cavallo

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

A dramatic enhancement of the diastereo- and enantioselectivity in the nitro-Michael addition reaction organocatalysed by a commercially available α,α-l-diaryl prolinol was disclosed when performing the reaction in unconventional hexafluorobenzene as a medium. DFT calculations were performed to clarify the origin of stereoselectivity and the role of C 6F 6. © The Royal Society of Chemistry 2012.
Original languageEnglish (US)
Pages (from-to)1650-1652
Number of pages3
JournalChem. Commun.
Volume48
Issue number11
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Ceramics and Composites
  • Chemistry(all)
  • Catalysis
  • Electronic, Optical and Magnetic Materials

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