The Handbook of Spatial Epidemiology is an edited anthology of chapters written by experts in the field that cover a wide range of methods used to understand the geographic and temporal patterns of health events, assess their relationship with potential risk factors, detect clusters, measure inequalities, and evaluate the impact of interventions. It can serve as an excellent reference for statisticians interested in the development of spatial epidemiology methods and their application. The handbook provides a thorough catalog of important theoretical models and a number of well-chosen applications, as well as a detailed discussion of the specific issues that need to be taken into account in spatial epidemiology investigations. The models are presented at an advanced level, so in general the handbook will be most useful to those with considerable statistical training. However, some of the introductory chapters are broad enough to be approachable to students, researchers and public health specialists.