Growth of large-scale MoS2 nanosheets on double layered ZnCo2O4 for real-time in situ H2S monitoring in live cells.

Veerappan Mani, Shanthi Selvaraj, Nithiya Jeromiyas, Sheng-Tung Huang, Hiroya Ikeda, Yasuhiro Hayakawa, Suru Ponnusamy, Chellamuthu Muthamizhchelvan, Khaled N. Salama

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

There is an urgent need to develop in situ sensors that monitor the continued release of H2S from biological systems to understand H2S-related pathology and pharmacology. For this purpose, we have developed a molybdenum disulfide supported double-layered zinc cobaltite modified carbon cloth electrode (MoS2-ZnCo2O4-ZnCo2O4) based electrocatalytic sensor. The results of our study suggest that the MoS2-ZnCo2O4-ZnCo2O4 electrode has excellent electrocatalytic ability to oxidize H2S at physiological pH, in a minimized overpotential (+0.20 vs. Ag/AgCl) with an amplified current signal. MoS2 grown on double-layered ZnCo2O4 showed relatively better surface properties and electrochemical properties than MoS2 grown on single-layered ZnCo2O4. The sensor delivered excellent analytical parameters, such as low detection limit (5 nM), wide linear range (10 nM-1000 μM), appreciable stability (94.3%) and high selectivity (2.5-fold). The practicality of the method was tested in several major biological fluids. The electrode monitors the dynamics of bacterial H2S in real-time for up to 5 h with good cell viability. Our research shows that MoS2-ZnCo2O4-ZnCo2O4/carbon cloth is a robust and sensitive electrode to understand how bacteria seek to adjust their defense strategies under exogenously induced stress conditions.
Original languageEnglish (US)
JournalJournal of materials chemistry. B
DOIs
StatePublished - Jul 16 2020

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