Ground rules of the pluripotency gene regulatory network.

Mo Li, Juan Carlos Izpisua Belmonte

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine.
Original languageEnglish (US)
Pages (from-to)180-191
Number of pages12
JournalNature Reviews Genetics
Issue number3
StatePublished - Jan 3 2017


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