GRC5 and NMD3 function in translational control of gene expression and interact genetically

Thomas Karl, Kamil Önder, Rimantas Kodzius, Alena Pichová, Herbert Wimmer, Ali Thür, Harald Hundsberger, Michael Löffler, Torsten Klade, Anton Beyer, Michael Breitenbach, Lore Koller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The yeast gene, GRC5 (growth control), is a member of the highly conserved QM gene family, the human member of which has been associated with the suppression of Wilms' tumor. GRC5 encodes ribosomal protein L10, which is thought to play a regulatory role in the translational control of gene expression. A revertant screen identified four spontaneous revertants of the mutant grc5-1(t)s allele. Genetic and phenotypic analysis showed that these represent one gene, NMD3, and that the interaction of NMD3 and GRC5 is gene-specific. NMD3 was previously identified as a component of the nonsense-mediated mRNA decay pathway. The point mutations within NMD3 reported here may define a domain important for the functional interaction of Grc5p and Nmd3p.

Original languageEnglish (US)
Pages (from-to)419-429
Number of pages11
JournalCurrent Genetics
Volume34
Issue number6
DOIs
StatePublished - Feb 8 1999

Keywords

  • GRC5
  • NMD3
  • Saccharomyces cerevisiae
  • Translational control

ASJC Scopus subject areas

  • Genetics

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