Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex

Brigitte Voutsinos-Porche, Gilles Bonvento, Kohichi Tanaka, Pascal Steiner, Egbert Welker, Jean Yves Chatton, Pierre Magistretti, Luc Pellerin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

221 Scopus citations

Abstract

Neuron-glia interactions are essential for synaptic function, and glial glutamate (re)uptake plays a key role at glutamatergic synapses. In knockout mice, for either glial glutamate transporters, GLAST or GLT-1, a classical metabolic response to synaptic activation (i.e., enhancement of glucose utilization) is decreased at an early functional stage in the somatosensory barrel cortex following activation of whiskers. Investigation in vitro demonstrates that glial glutamate transport represents a critical step for triggering enhanced glucose utilization, but also lactate release from astrocytes through a mechanism involving changes in intracellular Na+ concentration. These data suggest that a metabolic crosstalk takes place between neurons and astrocytes in the developing cortex, which would be regulated by synaptic activity and mediated by glial glutamate transporters.

Original languageEnglish (US)
Pages (from-to)275-286
Number of pages12
JournalNeuron
Volume37
Issue number2
DOIs
StatePublished - Jan 23 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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