Glial Energy Metabolism: Overview

L. Pellerin*, Pierre Magistretti

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Astrocytes exhibit several unique metabolic features. They possess a reserve glycolytic capacity that is used to cope with the burden of gultamate recycling. They contain glycogen stores that can be mobilized to face high energy demands following intense neuronal activity. Astrocytes also play a pivotal role in the protection against radical oxygen species, notably by providing precursors for the synthesis of glutathione to neurons. In addition, they are essential to replenish the neuronal glutamate pool and maintain glutamatergic transmission by providing the precursor gultamine synthesized either from recycled gultamate or . de novo from gulcose. Together with synaptic elements, astrocytes constitute a metabolic unit of fundamental importance to ensure excitatory neurotransmission.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages783-788
Number of pages6
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Astrocyte
  • Glutamate
  • Glutathione
  • Glycogen
  • Lactate

ASJC Scopus subject areas

  • Neuroscience(all)

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