Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Chih-Hua Chao, Ju-Chien Cheng, Theo Goncalves, Kuo-Wei Huang, Chi-Chien Lin, Hui-Chi Huang, Syh-Yuan Hwang, Yang-Chang Wu

Research output: Contribution to journalArticlepeer-review

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Glaulactams A-C (1-3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.
Original languageEnglish (US)
JournalScientific Reports
Issue number1
StatePublished - Oct 18 2018


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