Geostatistical survival models for environmental risk assessment with large retrospective cohorts

Huan Jiang*, Patrick E. Brown, Haavard Rue, Silvia Shimakura

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Motivated by the problem of cancer risk assessment near a nuclear power generating station, the paper describes a methodology for fitting a spatially correlated survival model to large retrospective cohort data sets. Retrospective cohorts, which can be assembled inexpensively from population-based health databases, can partially account for lags between exposures and outcome of chronic diseases such as cancer. These data sets overcome one of the principal limitations of cross-sectional spatial analyses, though performing statistical inference requires accommodating censored and truncated event times as well as spatial dependence. The use of spatial survival models for large retrospective cohorts is described, and Bayesian inference using Markov random-field approximations and integrated nested Laplace approximations is presented. The method is applied to data from individuals living near Pickering Nuclear Generating Station in Canada, showing that the effect of ambient radiation on cancer is not statistically significant.

Original languageEnglish (US)
Pages (from-to)679-695
Number of pages17
JournalJournal of the Royal Statistical Society. Series A: Statistics in Society
Volume177
Issue number3
DOIs
StatePublished - Jan 1 2014

Keywords

  • Bayesian inference
  • Geostatistics
  • Integrated nested Laplace approximation
  • Risk assessment
  • Survival analysis

ASJC Scopus subject areas

  • Statistics and Probability
  • Social Sciences (miscellaneous)
  • Economics and Econometrics
  • Statistics, Probability and Uncertainty

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