Abstract
Original language | English (US) |
---|---|
Pages (from-to) | 238-242 |
Number of pages | 5 |
Journal | Nature |
Volume | 538 |
Issue number | 7624 |
DOIs | |
State | Published - Sep 21 2016 |
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Genomic analyses inform on migration events during the peopling of Eurasia. / Pagani, Luca; Lawson, Daniel John; Jagoda, Evelyn; Mörseburg, Alexander; Eriksson, Anders; Mitt, Mario; Clemente, Florian; Hudjashov, Georgi; DeGiorgio, Michael; Saag, Lauri; Wall, Jeffrey D.; Cardona, Alexia; Mägi, Reedik; Sayres, Melissa A. Wilson; Kaewert, Sarah; Inchley, Charlotte; Scheib, Christiana L.; Järve, Mari; Karmin, Monika; Jacobs, Guy S.; Antao, Tiago; Iliescu, Florin Mircea; Kushniarevich, Alena; Ayub, Qasim; Tyler-Smith, Chris; Xue, Yali; Yunusbayev, Bayazit; Tambets, Kristiina; Mallick, Chandana Basu; Saag, Lehti; Pocheshkhova, Elvira; Andriadze, George; Muller, Craig; Westaway, Michael C.; Lambert, David M.; Zoraqi, Grigor; Turdikulova, Shahlo; Dalimova, Dilbar; Sabitov, Zhaxylyk; Sultana, Gazi Nurun Nahar; Lachance, Joseph; Tishkoff, Sarah; Momynaliev, Kuvat; Isakova, Jainagul; Damba, Larisa D.; Gubina, Marina; Nymadawa, Pagbajabyn; Evseeva, Irina; Atramentova, Lubov; Utevska, Olga; Ricaut, François-Xavier; Brucato, Nicolas; Sudoyo, Herawati; Letellier, Thierry; Cox, Murray P.; Barashkov, Nikolay A.; Škaro, Vedrana; Mulahasanovic´, Lejla; Primorac, Dragan; Sahakyan, Hovhannes; Mormina, Maru; Eichstaedt, Christina A.; Lichman, Daria V.; Abdullah, Syafiq; Chaubey, Gyaneshwer; Wee, Joseph T. S.; Mihailov, Evelin; Karunas, Alexandra; Litvinov, Sergei; Khusainova, Rita; Ekomasova, Natalya; Akhmetova, Vita; Khidiyatova, Irina; Marjanović, Damir; Yepiskoposyan, Levon; Behar, Doron M.; Balanovska, Elena; Metspalu, Andres; Derenko, Miroslava; Malyarchuk, Boris; Voevoda, Mikhail; Fedorova, Sardana A.; Osipova, Ludmila P.; Lahr, Marta Mirazón; Gerbault, Pascale; Leavesley, Matthew; Migliano, Andrea Bamberg; Petraglia, Michael; Balanovsky, Oleg; Khusnutdinova, Elza K.; Metspalu, Ene; Thomas, Mark G.; Manica, Andrea; Nielsen, Rasmus; Villems, Richard; Willerslev, Eske; Kivisild, Toomas; Metspalu, Mait.
In: Nature, Vol. 538, No. 7624, 21.09.2016, p. 238-242.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Genomic analyses inform on migration events during the peopling of Eurasia
AU - Pagani, Luca
AU - Lawson, Daniel John
AU - Jagoda, Evelyn
AU - Mörseburg, Alexander
AU - Eriksson, Anders
AU - Mitt, Mario
AU - Clemente, Florian
AU - Hudjashov, Georgi
AU - DeGiorgio, Michael
AU - Saag, Lauri
AU - Wall, Jeffrey D.
AU - Cardona, Alexia
AU - Mägi, Reedik
AU - Sayres, Melissa A. Wilson
AU - Kaewert, Sarah
AU - Inchley, Charlotte
AU - Scheib, Christiana L.
AU - Järve, Mari
AU - Karmin, Monika
AU - Jacobs, Guy S.
AU - Antao, Tiago
AU - Iliescu, Florin Mircea
AU - Kushniarevich, Alena
AU - Ayub, Qasim
AU - Tyler-Smith, Chris
AU - Xue, Yali
AU - Yunusbayev, Bayazit
AU - Tambets, Kristiina
AU - Mallick, Chandana Basu
AU - Saag, Lehti
AU - Pocheshkhova, Elvira
AU - Andriadze, George
AU - Muller, Craig
AU - Westaway, Michael C.
AU - Lambert, David M.
AU - Zoraqi, Grigor
AU - Turdikulova, Shahlo
AU - Dalimova, Dilbar
AU - Sabitov, Zhaxylyk
AU - Sultana, Gazi Nurun Nahar
AU - Lachance, Joseph
AU - Tishkoff, Sarah
AU - Momynaliev, Kuvat
AU - Isakova, Jainagul
AU - Damba, Larisa D.
AU - Gubina, Marina
AU - Nymadawa, Pagbajabyn
AU - Evseeva, Irina
AU - Atramentova, Lubov
AU - Utevska, Olga
AU - Ricaut, François-Xavier
AU - Brucato, Nicolas
AU - Sudoyo, Herawati
AU - Letellier, Thierry
AU - Cox, Murray P.
AU - Barashkov, Nikolay A.
AU - Škaro, Vedrana
AU - Mulahasanovic´, Lejla
AU - Primorac, Dragan
AU - Sahakyan, Hovhannes
AU - Mormina, Maru
AU - Eichstaedt, Christina A.
AU - Lichman, Daria V.
AU - Abdullah, Syafiq
AU - Chaubey, Gyaneshwer
AU - Wee, Joseph T. S.
AU - Mihailov, Evelin
AU - Karunas, Alexandra
AU - Litvinov, Sergei
AU - Khusainova, Rita
AU - Ekomasova, Natalya
AU - Akhmetova, Vita
AU - Khidiyatova, Irina
AU - Marjanović, Damir
AU - Yepiskoposyan, Levon
AU - Behar, Doron M.
AU - Balanovska, Elena
AU - Metspalu, Andres
AU - Derenko, Miroslava
AU - Malyarchuk, Boris
AU - Voevoda, Mikhail
AU - Fedorova, Sardana A.
AU - Osipova, Ludmila P.
AU - Lahr, Marta Mirazón
AU - Gerbault, Pascale
AU - Leavesley, Matthew
AU - Migliano, Andrea Bamberg
AU - Petraglia, Michael
AU - Balanovsky, Oleg
AU - Khusnutdinova, Elza K.
AU - Metspalu, Ene
AU - Thomas, Mark G.
AU - Manica, Andrea
AU - Nielsen, Rasmus
AU - Villems, Richard
AU - Willerslev, Eske
AU - Kivisild, Toomas
AU - Metspalu, Mait
N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: Support was provided by: Estonian Research Infrastructure Roadmap grant no 3.2.0304.11-0312; Australian Research Council Discovery grants (DP110102635 and DP140101405) (D.M.L., M.W. and E.W.); Danish National Research Foundation; the Lundbeck Foundation and KU2016 (E.W.); ERC Starting Investigator grant (FP7 - 261213) (T.K.); Estonian Research Council grant PUT766 (G.C. and M.K.); EU European Regional Development Fund through the Centre of Excellence in Genomics to Estonian Biocentre (R.V.; M.Me. and A.Me.), and Centre of Excellence for Genomics and Translational Medicine Project No. 2014-2020.4.01.15-0012 to EGC of UT (A.Me.) and EBC (M.Me.); Estonian Institutional Research grant IUT24-1 (L.S., M.J., A.K., B.Y., K.T., C.B.M., Le.S., H.Sa., S.L., D.M.B., E.M., R.V., G.H., M.K., G.C., T.K. and M.Me.) and IUT20-60 (A.Me.); French Ministry of Foreign and European Affairs and French ANR grant number ANR-14-CE31-0013-01 (F.-X.R.); Gates Cambridge Trust Funding (E.J.); ICG SB RAS (No. VI.58.1.1) (D.V.L.); Leverhulme Programme grant no. RP2011-R-045 (A.B.M., P.G. and M.G.T.); Ministry of Education and Science of Russia; Project 6.656.2014/K (S.A.F.); NEFREX grant funded by the European Union (People Marie Curie Actions; International Research Staff Exchange Scheme; call FP7-PEOPLE-2012-IRSES-number 318979) (M.Me., G.H. and M.K.); NIH grants 5DP1ES022577 05, 1R01DK104339-01, and 1R01GM113657-01 (S.Tis.); Russian Foundation for Basic Research (grant N 14-06-00180a) (M.G.); Russian Foundation for Basic Research; grant 16-04-00890 (O.B. and E.B); Russian Science Foundation grant 14-14-00827 (O.B.); The Russian Foundation for Basic Research (14-04-00725-a), The Russian Humanitarian Scientific Foundation (13-11-02014) and the Program of the Basic Research of the RAS Presidium “Biological diversity” (E.K.K.); Wellcome Trust and Royal Society grant WT104125AIA & the Bristol Advanced Computing Research Centre (http://www.bris.ac.uk/acrc/) (D.J.L.); Wellcome Trust grant 098051 (Q.A.; C.T.-S. and Y.X.); Wellcome Trust Senior Research Fellowship grant 100719/Z/12/Z (M.G.T.); Young Explorers Grant from the National Geographic Society (8900-11) (C.A.E.); ERC Consolidator Grant 647787 ‘LocalAdaptatio’ (A.Ma.); Program of the RAS Presidium “Basic research for the development of the Russian Arctic” (B.M.); Russian Foundation for Basic Research grant 16-06-00303 (E.B.); a Rutherford Fellowship (RDF-10-MAU-001) from the Royal Society of New Zealand (M.P.C.).
PY - 2016/9/21
Y1 - 2016/9/21
N2 - High-Coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population history and refuelled the debate on the mutation rate in humans. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long-and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record, and admixture between AMHs and Neanderthals predating the main Eurasian expansion, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago. © 2016 Macmillan Publishers Limited, part of Springer Nature.
AB - High-Coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population history and refuelled the debate on the mutation rate in humans. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long-and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record, and admixture between AMHs and Neanderthals predating the main Eurasian expansion, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago. © 2016 Macmillan Publishers Limited, part of Springer Nature.
UR - http://hdl.handle.net/10754/622409
UR - http://www.nature.com/nature/journal/v538/n7624/full/nature19792.html
UR - http://www.scopus.com/inward/record.url?scp=84981502573&partnerID=8YFLogxK
U2 - 10.1038/nature19792
DO - 10.1038/nature19792
M3 - Article
C2 - 27654910
VL - 538
SP - 238
EP - 242
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7624
ER -