TY - JOUR
T1 - Generation of tunable and pulsatile concentration gradients via microfluidic network
AU - Zhou, Bingpu
AU - Xu, Wei
AU - Wang, Cong
AU - Chau, Yeungyeung
AU - Zeng, Xiping
AU - Zhang, Xixiang
AU - Shen, Rong
AU - Wen, Weijia
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): SA-C0040/UK-C0016
Acknowledgements: We would like to thank Prof. Andrew W. O. Poon's research group, of Department of Electronic and Computer Engineering in HKUST, for their assistance in COMSOL Multiphysics simulations. This publication is based on work partially supported by Award No. SA-C0040/UK-C0016, made by King Abdullah University of Science and Technology (KAUST), Hong Kong RGC Grants HKUST 604710 and 605411, and National Natural Science Foundation of China (Grant No. 11290165). The work is also partially supported by the Nanoscience and Nanotechnology Program at HKUST.
PY - 2014/6/4
Y1 - 2014/6/4
N2 - We demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.
AB - We demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.
UR - http://hdl.handle.net/10754/563591
UR - http://link.springer.com/10.1007/s10404-014-1432-9
UR - http://www.scopus.com/inward/record.url?scp=84922000426&partnerID=8YFLogxK
U2 - 10.1007/s10404-014-1432-9
DO - 10.1007/s10404-014-1432-9
M3 - Article
VL - 18
SP - 175
EP - 184
JO - Microfluidics and Nanofluidics
JF - Microfluidics and Nanofluidics
SN - 1613-4982
IS - 2
ER -