Generation of tunable and pulsatile concentration gradients via microfluidic network

Bingpu Zhou, Wei Xu, Cong Wang, Yeungyeung Chau, Xiping Zeng, Xixiang Zhang, Rong Shen, Weijia Wen

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.
Original languageEnglish (US)
Pages (from-to)175-184
Number of pages10
JournalMicrofluidics and Nanofluidics
Volume18
Issue number2
DOIs
StatePublished - Jun 4 2014

ASJC Scopus subject areas

  • Materials Chemistry
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Generation of tunable and pulsatile concentration gradients via microfluidic network'. Together they form a unique fingerprint.

Cite this