GABAB-ergic modulation of burst rate and intersegmental coordination in lamprey: Experiments and simulations

Jesper Tegner*, Sten Grillner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Neuromodulators which influence the operation of neural networks act as a rule via several cellular and synaptic mechanisms. Activation of GABAB-receptors in the lamprey spinal cord reduce both calcium currents and the peak amplitude of the post-spike afterhyperpolarization (AHP). Activation of GABAB-receptors reduce the segmental alternation rate and modifies the intersegmental coordination when the spinal locomotor circuits are activated by NMDA. Using physiological experiments we find that a reduced AHP is not sufficient to account for the observed reduction of the burst rate. Computer simulations revealed that either a reduced AHP or calcium current could alter the phase coordination between the segments similar to earlier experiments.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalBrain Research
Volume864
Issue number1
DOIs
StatePublished - May 5 2000

Keywords

  • Afterhyperpolarization
  • Calcium channels
  • Intersegmental coordination
  • Motor control
  • NMDA
  • Phase lag

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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