Functionalization of cellulose dialysis membranes for chiral separation using beta-cyclodextrin immobilization

Youchang Xiao, Tai-Shung Chung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

A membrane-based chiral separation system for the separation of racemic tryptophan solutions is developed by the covalently binding beta-cyclodextrin onto the surface of commercial cellulose membranes. The immobilization process is monitored by XPS. AFM demonstrates the evolutionary transition of membrane surface morphology before and after the CD immobilization. Due to their different complexation with immobilized CD, dialysis transport experiments show d-tryptophan preferential permeability through the immobilized CD membranes, and the enantioselectivity is 1.10. A model based on the existence of a thin chiral solution layer of amino acid at the interface between the feed solution and the membrane has been proposed. This chiral separation model has been verified using the chiral separation results of racemic amino acids and binding constants of amino acids with CD. The effect of membrane's pore size on enantioselectivity has also been investigated. The immobilized CD membrane, having MWCO 1000, exhibits the highest enantioselectivity to the racemic tryptophan solution.

Original languageEnglish (US)
Pages (from-to)78-85
Number of pages8
JournalJournal of Membrane Science
Volume290
Issue number1-2
DOIs
StatePublished - Apr 1 2007

Keywords

  • Cellulose membrane
  • Chiral separation
  • Dialysis
  • Immobilization

ASJC Scopus subject areas

  • Filtration and Separation
  • Polymers and Plastics

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