Four new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestis

Ling-Li Liu, Ying Xu, Zhuang Han, Yong-Xin Li, Liang Lu, Pok-Yui Lai, Jia-Liang Zhong, Xianrong Guo, Xixiang Zhang, Pei-Yuan Qian

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33 Scopus citations

Abstract

Four new polycyclic antibiotics, citreamicin ? A (1), citreamicin ? B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin ? A (1), citreamicin ? B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 ?g/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. 2012 by the authors; licensee MDPI.
Original languageEnglish (US)
Pages (from-to)2571-2583
Number of pages13
JournalMarine Drugs
Volume10
Issue number12
DOIs
StatePublished - Nov 20 2012

ASJC Scopus subject areas

  • Drug Discovery

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