Forskolin but not isoprenaline increases sodium current from frog cardiac myocytes

R. Bonvallet*, F. Lemtiri-Chlieh, O. Rougier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch‐clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between ‐50 and +30 mV. The forskolin‐induced increase of INa was mimicked by 1,9‐dideoxyforskolin (0.5 microM) but not by isoprenaline (2 microM). These results suggest that forskolin can modulate INa through a mechanism that does not involve the production of cyclic AMP.

Original languageEnglish (US)
Pages (from-to)843-846
Number of pages4
JournalExperimental Physiology
Volume75
Issue number6
DOIs
StatePublished - Nov 1 1990

ASJC Scopus subject areas

  • Physiology

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