Finite element method on numerical simulation of stratum corneum's penetration property

Yu Hong Liu*, Ai Ke Qiao, Dirk Feuchter, Gabriel Wittum, Yan Jun Zeng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

How the outer substance could penetrate through the skin lies in the stratum corneum, because it is the main barrier in the multi-layers of the skin. Supposing the keratin cell with a special geometry as tetrakaidecahedron, the penetration property of stratum corneum was the key problem which was numerically simulated with finite element method. At first the discretization of the stratum corneum region was given in two steps: first, the discretization of the keratin cell; second, the discretization of fattiness that surrounds the keratin. Then there was the work of numerical simulation. In this procedure, the finite element method and the multi-grid method were used. The former was to obtain the discretization of basic elements; the latter was to decrease the high frequency error. At last the visualization of the numerical simulation was shown.

Original languageEnglish (US)
Pages (from-to)469-475
Number of pages7
JournalApplied Mathematics and Mechanics (English Edition)
Volume27
Issue number4
DOIs
StatePublished - Apr 1 2006

Keywords

  • Discretization
  • Finite element method
  • Multi-grid method
  • Stratum corneum
  • Tetrakaidecahedron

ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering
  • Applied Mathematics

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