Finding functional promoter motifs by computational methods: A word of caution

Rajesh Chowdhary, Limsoon Wong, Vladimir Bajic*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The standard practice in the analysis of promoters is to select promoter regions of convenient length. This may lead to false results when searching for Transcription Factor Binding Sites (TFBSs), since the sequences may contain coding segments. In such cases, motif detection may single out motifs from the coding regions. The mapping of TFBSs to promoters may result in a misleading picture of 'promoter' content. We illustrate these issues using the example of histones H2A and H2B and show how such analysis could be misleading if care is not exercised to eliminate coding regions from the presumed promoter sequences.

Original languageEnglish (US)
Pages (from-to)282-288
Number of pages7
JournalInternational Journal of Bioinformatics Research and Applications
Volume2
Issue number3
DOIs
StatePublished - Jan 1 2006

Keywords

  • Motifs
  • Promoter
  • Transcription Factor Binding Sites (TFBSs)
  • Transcription Start Sites (TSSs)
  • Translation Initiation Sites (TIS)

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Clinical Biochemistry
  • Health Information Management

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