FIDEA: a server for the functional interpretation of differential expression analysis.

Daniel D'Andrea, Luigi Grassi, Mariagiovanna Mazzapioda, Anna Tramontano

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The results of differential expression analyses provide scientists with hundreds to thousands of differentially expressed genes that need to be interpreted in light of the biology of the specific system under study. This requires mapping the genes to functional classifications that can be, for example, the KEGG pathways or InterPro families they belong to, their GO Molecular Function, Biological Process or Cellular Component. A statistically significant overrepresentation of one or more category terms in the set of differentially expressed genes is an essential step for the interpretation of the biological significance of the results. Ideally, the analysis should be performed by scientists who are well acquainted with the biological problem, as they have a wealth of knowledge about the system and can, more easily than a bioinformatician, discover less obvious and, therefore, more interesting relationships. To allow experimentalists to explore their data in an easy and at the same time exhaustive fashion within a single tool and to test their hypothesis quickly and effortlessly, we developed FIDEA. The FIDEA server is located at http://www.biocomputing.it/fidea; it is free and open to all users, and there is no login requirement.
Original languageEnglish (US)
Pages (from-to)W84-W88
Number of pages1
JournalNucleic Acids Research
Volume41
Issue numberW1
DOIs
StatePublished - Jun 10 2013
Externally publishedYes

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