Fast and scalable inference of multi-sample cancer lineages.

Victoria Popic, Raheleh Salari, Iman Hajirasouliha, Dorna Kashef-Haghighi, Robert B West, Serafim Batzoglou

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Somatic variants can be used as lineage markers for the phylogenetic reconstruction of cancer evolution. Since somatic phylogenetics is complicated by sample heterogeneity, novel specialized tree-building methods are required for cancer phylogeny reconstruction. We present LICHeE (Lineage Inference for Cancer Heterogeneity and Evolution), a novel method that automates the phylogenetic inference of cancer progression from multiple somatic samples. LICHeE uses variant allele frequencies of somatic single nucleotide variants obtained by deep sequencing to reconstruct multi-sample cell lineage trees and infer the subclonal composition of the samples. LICHeE is open source and available at http://viq854.github.io/lichee .
Original languageEnglish (US)
JournalGenome Biology
Volume16
Issue number1
DOIs
StatePublished - May 6 2015
Externally publishedYes

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