Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala

Igor Allaman, Mariusz Papp, Rudolf Krafsik, Hubert Fiumelli, Pierre J. Magistretti, Jean Luc Martin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Accumulating evidence supports a role for brain-derived neurotrophic factor (BDNF) in depression. However, most of these studies have been performed in animal models that have a low face validity with regard to the human disease. Here, we examined the regulation of BDNF expression in the hippocampus and amygdala of rats subjected to the chronic mild stress (CMS) model of depression, a paradigm that induces anhedonia, a core symptom of depression. We found that exposure of rats to the CMS paradigm did not modulate BDNF mRNA expression in the hippocampus and amygdala. In addition, chronic administration of imipramine, which reversed CMS-induced anhedonia, did not alter BDNF mRNA expression in these limbic structures.

Original languageEnglish (US)
Pages (from-to)1001-1007
Number of pages7
JournalPharmacological Reports
Volume60
Issue number6
StatePublished - 2008
Externally publishedYes

Keywords

  • Anhedonia
  • BDNF
  • Chronic mildstress
  • Depression
  • Imipramine

ASJC Scopus subject areas

  • Pharmacology

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