Exploring the genetics underlying autoimmune diseases with network analysis and link prediction

Gregorio Alanis Lobato, Carlo Cannistraci, Timothy Ravasi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Ever since the first Genome Wide Association Study (GWAS) was carried out we have seen an important number of discoveries of biological and clinical relevance. However, there are some scientists that consider that these research outcomes and their utility are far from what was expected from this experimental design. We instead believe that the thousands of genetic variants associated with complex disorders by means of GWASs are an extremely valuable source of information that needs to be mined in a different way. Based on this philosophy, we followed a holistic perspective to analyze GWAS data and explored the structural properties of the network representation of one of these datasets with the aim to advance our understanding of the genetic intricacies underlying autoimmune human diseases. The simplicity, computational efficiency and precision of the tools proposed in this paper represent a new means to address GWAS data and contribute to the better exploitation of these rich sources of information. © 2014 IEEE.
Original languageEnglish (US)
Title of host publication2nd Middle East Conference on Biomedical Engineering
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages167-170
Number of pages4
ISBN (Print)9781479947997
DOIs
StatePublished - Feb 2014

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