Exploration of miRNA families for hypotheses generation.

T.K. Kamanu, Aleksandar Radovanovic, John A.C. Archer, Vladimir B. Bajic

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhance investigation of characteristics of miRNA families and the functions of family-specific miRNA genes are lacking. We have developed, miRNAVISA, a user-friendly web-based tool that allows customized interrogation and comparisons of miRNA families for hypotheses generation, and comparison of per-species chromosomal distribution of miRNA genes in different families. This study illustrates hypothesis generation using miRNAVISA in seven species. Our results unveil a subclass of miRNAs that may be regulated by genomic imprinting, and also suggest that some miRNA families may be species-specific, as well as chromosome- and/or strand-specific.
Original languageEnglish (US)
JournalScientific reports
Volume3
Issue number1
DOIs
StatePublished - Oct 15 2013

ASJC Scopus subject areas

  • General

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