Exploitation of genetic interaction network topology for the prediction of epistatic behavior

Gregorio Alanis Lobato, Carlo Cannistraci, Timothy Ravasi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Genetic interaction (GI) detection impacts the understanding of human disease and the ability to design personalized treatment. The mapping of every GI in most organisms is far from complete due to the combinatorial amount of gene deletions and knockdowns required. Computational techniques to predict new interactions based only on network topology have been developed in network science but never applied to GI networks.We show that topological prediction of GIs is possible with high precision and propose a graph dissimilarity index that is able to provide robust prediction in both dense and sparse networks.Computational prediction of GIs is a strong tool to aid high-throughput GI determination. The dissimilarity index we propose in this article is able to attain precise predictions that reduce the universe of candidate GIs to test in the lab. © 2013 Elsevier Inc.
Original languageEnglish (US)
Pages (from-to)202-208
Number of pages7
JournalGenomics
Volume102
Issue number4
DOIs
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Genetics

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