Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents

Ken Ichi Ohba, Masashi Mizokami*, Johnson Y.N. Lau, Etsuro Orito, Kazuho Ikeo, Takashi Gojobori

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Two flavivirus-like viruses, GB virus-A (GBV-A) and GB virus-B (GBV-B), were recently identified in the GB hepatitis agent, and are distinct from the hepatitis A to E viruses. The putative helicase domain of GBV-A and GBV-B was found to have amino acid sequence homology with hepatitis C virus (HCV), and distantly, is also related to pestiviruses, flaviviruses, and plant viruses. A phylogenetic tree construction showed that GBVs and HCV are closely related, and they are clustered with pestiviruses, flaviviruses and plant viruses in that order.

Original languageEnglish (US)
Pages (from-to)232-234
Number of pages3
JournalFEBS Letters
Volume378
Issue number3
DOIs
StatePublished - Jan 15 1996

Keywords

  • Evolution
  • GB virus
  • HCV
  • Phylogenetic tree

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents'. Together they form a unique fingerprint.

Cite this