Evaluation of microfluidic channels with optical coherence tomography

J. Czajkowski, T. Prykäri, Erkki Alarousu, J. Lauri, R. Myllylä

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Application of time domain, ultra high resolution optical coherence tomography (UHR-OCT) in evaluation of microfluidic channels is demonstrated. Presented study was done using experimental UHR-OCT device based on a Kerr-lens mode locked Ti:sapphire femtosecond laser, a photonic crystal fibre and modified, free-space Michelson interferometer. To show potential of the technique, microfluidic chip fabricated by VTT Center for Printed Intelligence (Oulu, Finland) was measured. Ability for full volumetric reconstruction in non-contact manner enabled complete characterization of closed entity of a microfluidic channel without contamination and harm for the sample. Measurement, occurring problems, and methods of postprocessing for raw data are described. Results present completely resolved physical structure of the channel, its spatial dimensions, draft angles and evaluation of lamination quality.
Original languageEnglish (US)
Title of host publicationLaser Applications in Life Sciences
PublisherSPIE-Intl Soc Optical Eng
ISBN (Print)9780819476524
DOIs
StatePublished - Jun 25 2010

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