Enzymatically triggered multifunctional delivery system based on hyaluronic acid micelles

Lin Deng, Guangchao Wang, Jian Ren, Bei Zhang, Jingjing Yan, Wengang Li, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Tumor targetability and stimuli responsivity of drug delivery systems (DDS) are key factors in cancer therapy. Implementation of multifunctional DDS can afford targetability and responsivity at the same time. Herein, cholesterol molecules (Ch) were coupled to hyaluronic acid (HA) backbones to afford amphiphilic conjugates that can self-assemble into stable micelles. Doxorubicin (DOX), an anticancer drug, and superparamagnetic iron oxide (SPIO) nanoparticles (NPs), magnetic resonance imaging (MRI) contrast agents, were encapsulated by Ch-HA micelles and were selectively released in the presence of hyaluronidase (Hyals) enzyme. Cytotoxicity and cell uptake studies were done using three cancer cell lines (HeLa, HepG2 and MCF7) and one normal cell line (WI38). Higher Ch-HA micelles uptake was seen in cancer cells versus normal cells. Consequently, DOX release was elevated in cancer cells causing higher cytotoxicity and enhanced cell death. © 2012 The Royal Society of Chemistry.
Original languageEnglish (US)
Pages (from-to)12909
JournalRSC Advances
Volume2
Issue number33
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

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