Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging

Yevhen Fatieiev, Jonas G. Croissant, Khachatur Julfakyan, Lin Deng, Dalaver H. Anjum, Andrei Gurinov, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Non-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.
Original languageEnglish (US)
Pages (from-to)15046-15050
Number of pages5
JournalNanoscale
Volume7
Issue number37
DOIs
StatePublished - 2015

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