Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation

Gianni Ciofani*, Serena Danti, Delfo D'Alessandro, Leonardo Ricotti, Stefania Moscato, Giovanni Bertoni, Andrea Falqui, Stefano Berrettini, Mario Petrini, Virgilio Mattoli, Arianna Menciassi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

In this paper, we propose an absolutely innovative technique for the electrical stimulation of cells, based on piezoelectric nanoparticles. Ultrasounds are used to impart mechanical stress to boron nitride nanotubes incubated with neuronal-like PC12 cells. By virtue of their piezoelectric properties, these nanotubes can polarize and convey electrical stimuli to the cells. PC12 stimulated with the present method exhibit neurite sprout 30% greater than the control cultures after 9 days of treatment.

Original languageEnglish (US)
Pages (from-to)6267-6277
Number of pages11
JournalACS Nano
Volume4
Issue number10
DOIs
StatePublished - Oct 26 2010

Keywords

  • PC12 cells
  • boron nitride nanotubes
  • neuronal regeneration
  • piezoelectric stimulation

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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