Enantiospecific kinking of DNA by a partially intercalating metal complex

Anna Reymer, Bengt Nordén

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Opposite enantiomers of [Ru(phenanthroline) 3] 2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins. © The Royal Society of Chemistry 2012.
Original languageEnglish (US)
Pages (from-to)4941
JournalChemical Communications
Volume48
Issue number41
DOIs
StatePublished - 2012
Externally publishedYes

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