Enantioselective synthesis of quinolizidines and indolizidines via a catalytic asymmetric hydrogenation cascade

Magnus Rueping*, Lukas Hubener

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

A catalytic enantioselective synthesis of a new class of quinolizidines and indolizidines is presented. An asymmetric Bronsted acid catalyzed hydrogenation cascade as well as a sequential Bronsted acid/metal catalyzed hydrogenation protocol of 2-substituted quinolines yields benzofused quinolizidines and indolizidines in good yields with high diastereo- and enantioselectivities.

Original languageEnglish (US)
Article numberY03411ST
Pages (from-to)1243-1246
Number of pages4
JournalSynlett
Issue number9
DOIs
StatePublished - May 30 2011

Keywords

  • Hantzsch ester
  • amines
  • asymmetric reduction
  • domino reaction
  • organocatalysis

ASJC Scopus subject areas

  • Organic Chemistry

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