TY - JOUR
T1 - Electrochemical and Scalable Dehydrogenative C(sp
3
)−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow
AU - Nikolaienko, Pavlo
AU - Jentsch, Marc
AU - Kale, Ajit P.
AU - Cai, Yunfei
AU - Rueping, Magnus
N1 - KAUST Repository Item: Exported on 2021-02-21
Acknowledged KAUST grant number(s): URF/1/1974-04-01
Acknowledgements: This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/1974-04-01).
PY - 2019/5/2
Y1 - 2019/5/2
N2 - A hydrogen atom transfer-directed electrochemical intramolecular C−H amination has been developed in which the N-radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.
AB - A hydrogen atom transfer-directed electrochemical intramolecular C−H amination has been developed in which the N-radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.
UR - http://hdl.handle.net/10754/653109
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201806092
UR - http://www.scopus.com/inward/record.url?scp=85065298565&partnerID=8YFLogxK
U2 - 10.1002/chem.201806092
DO - 10.1002/chem.201806092
M3 - Article
C2 - 30861204
AN - SCOPUS:85065298565
VL - 25
SP - 7177
EP - 7184
JO - Chemistry – A European Journal
JF - Chemistry – A European Journal
SN - 0947-6539
IS - 29
ER -