Electrochemical and Scalable Dehydrogenative C(sp 3 )−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow

Pavlo Nikolaienko, Marc Jentsch, Ajit P. Kale, Yunfei Cai, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A hydrogen atom transfer-directed electrochemical intramolecular C−H amination has been developed in which the N-radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.
Original languageEnglish (US)
Pages (from-to)7177-7184
Number of pages8
JournalChemistry – A European Journal
Volume25
Issue number29
DOIs
StatePublished - May 2 2019

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