Electrical detection of DNA hybridization with single-base specificity using transistors based on CVD-grown graphene sheets

Xiaochen Dong*, Yumeng Shi, Wei Huang, Peng Chen, Lain-Jong Li

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

421 Scopus citations

Abstract

Large-sized chemical vapor deposited graphene films configured as solutiongated transistors can label-freely and electrically detect DNA hybridization with single-base specificity. The gate voltage which gives the minimum device conductance (Vg.min) is sensitive to the charge transfer between DNA molecules and graphene, and thus is used to detect the DNA hybridization. The DNA detection is attributed to the electronic n-doping from DNA to graphene rather than the electrostatic gating effect or impurity screening effect. Chemical Equation Presentation

Original languageEnglish (US)
Pages (from-to)1649-1653
Number of pages5
JournalAdvanced Materials
Volume22
Issue number14
DOIs
StatePublished - Apr 12 2010

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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