Efficient separation of small molecules using a large surface area hypercrosslinked monolithic polymer capillary column

Jiri Urban, Frantisek Svec, Jean Frechet

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

Monolithic poly(styrene-co-vinylbenzyl chloride-co-divinylbenzene) precursor capillary columns have been prepared and then hypercrosslinked to afford a monolith containing an array of small pores. This monolithic column exhibited a surface area of 663 m2/g or more than 1 order of magnitude larger than measured for the precursor column. Because it contains mesopores, this monolithic column affords good separation of uracil and alkylbenzenes in isocratic mobile phase mode and also proved useful for separations in size exclusion mode. A column efficiency as high as 73000 plates/m was determined for uracil. In contrast, the presence of mesopores in this hypercrosslinked monolithic column had a detrimental effect on the separation of proteins.

Original languageEnglish (US)
Pages (from-to)1621-1623
Number of pages3
JournalAnalytical Chemistry
Volume82
Issue number5
DOIs
StatePublished - Mar 1 2010

ASJC Scopus subject areas

  • Analytical Chemistry

Fingerprint Dive into the research topics of 'Efficient separation of small molecules using a large surface area hypercrosslinked monolithic polymer capillary column'. Together they form a unique fingerprint.

Cite this