Efficient metal-catalyzed direct benzylation and allylic alkylation of 2,4-pentanediones

Magnus Rueping*, Boris J. Nachtsheim, Alexander Kuenkel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

(Chemical Equation Presented) A highly effective metal-catalyzed benzylation and allylic alkylation of 2,4-pentanediones has been developed. This new bismuth-catalyzed direct carbon-carbon bond forming reaction provides the corresponding monoalkylated dicarbonyl compounds in high yields after short reaction times using the lowest amounts of catalyst (1 mol %) and the free alcohol. In addition, a new route to substituted indenes is presented.

Original languageEnglish (US)
Pages (from-to)825-828
Number of pages4
JournalOrganic Letters
Volume9
Issue number5
DOIs
StatePublished - Mar 1 2007

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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