Efficient enantioselective synthesis of optically active diols by asymmetric hydrogénation with modular chiral metal catalysts

Renat Kadyrov*, René M. Koenigs, Claus Brinkmann, David Voigtlaender, Magnus Rueping

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Valuable vicinal 1,2-diols can be prepared with high enantioselectivity by the asymmetric ruthenium-catalyzed hydrogenation of aryl- and alkyl-substituted -hydroxy ketones (see scheme). The ligands, which are distinguished by their modular construction, display excellent enantioface differentiation.

Original languageEnglish (US)
Pages (from-to)7556-7559
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number41
DOIs
StatePublished - Sep 28 2009

Keywords

  • Asymmetric synthesis
  • Diols
  • Hydrogenation
  • Phosphanes
  • Ruthenium complexes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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