Effects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops)

Chesa G. Chauke, Zainunisha Arieff, Mandeep Kaur, Jürgen V. Seier

Research output: Contribution to journalArticlepeer-review

Abstract

Niacin is the most effective drug available for raising levels of high-density lipoprotein (HDL) cholesterol. To evaluate its effects on plasma lipid concentrations, the authors administered a low dose of niacin to healthy, adult, female African green monkeys for 3 months. In the treated monkeys, low-density lipoprotein cholesterol concentrations decreased by 43% from baseline, whereas concentrations of HDL cholesterol and apolipoprotein A-I increased by 49% and 34%, respectively. The results suggest that in this primate model, a low dose of niacin can effectively increase concentrations of HDL cholesterol.©2014 Nature America, Inc. All rights reserved.
Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalLab Animal
Volume43
Issue number2
DOIs
StatePublished - Feb 1 2014

ASJC Scopus subject areas

  • veterinary(all)
  • Animal Science and Zoology

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