Effect of the modifier on the particle formation and crystallisation behaviour during precipitation from aqueous solutions

Andréanne Bouchard*, Nataša Jovanović, Ángel Martín, Gerard W. Hofland, Daan J.A. Crommelin, Wim Jiskoot, Geert Jan Witkamp

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Ethanol is a commonly added modifier to supercritical CO2 for particle formation from aqueous solutions. Four modifiers - methanol, ethanol, 2-propanol and acetone - were studied to determine the extent of the effect of the modifier selection on the particles produced and to determine more precisely the precipitation mechanisms. The strong anti-solvent effect of methanol on the solute was shown by the production of metastable β-glycine, phenylalanine anhydrate and lysozyme agglomerated nanoparticles. Ethanol showed such an anti-solvent effect only when use at higher fraction in the supercritical phase, followed by 2-propanol and acetone. 2-Propanol and acetone mainly contributed to the precipitation of the solute by increasing the solubility of the water in the supercritical phase. In such precipitation conditions the more stable α-glycine, phenylalanine monohydrate and lysozyme microspheres were produced by the evaporation of the solution into the CO2 phase. The putative anti-solvent effect of CO2 in the systems studied was not clearly observed, but it remains that CO2 is essential to the SCF-drying process.

Original languageEnglish (US)
Pages (from-to)409-421
Number of pages13
JournalJournal of Supercritical Fluids
Volume44
Issue number3
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Keywords

  • Amorphous
  • Aqueous solutions
  • Crystallisation
  • Organic solvents
  • Polymorph

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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