Early detection of G + C differences in bacterial species inferred from the comparative analysis of the two completely sequenced Helicobacter pylori strains

Matthew Bellgard*, David Schibeci, Edward Trifonov, Takashi Gojobori

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Identifying the G + C difference between closely related bacterial species or between different strains of the same species is one of the first steps in understanding the evolutionary mechanisms accounting for the differences observed among bacterial species. The G + C content can be one of the most important factors in the evolution of genomic structures. In this paper, we describe a new method for detecting an initial stage of differentiation of the G + C content at the third codon base position between two strains of the same bacterial species. We apply this method to the two strains of Helicobacter pylori. A group of genes is detected with large variations of G + C in the third positions-apparently genes of early response to pressures of changing G + C. We discuss our findings from the viewpoint of genomic evolution.

Original languageEnglish (US)
Pages (from-to)465-468
Number of pages4
JournalJournal of Molecular Evolution
Volume53
Issue number4-5
DOIs
StatePublished - Oct 3 2001

Keywords

  • Complete genome sequences
  • G + C content
  • Helicobacter pylori

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

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