Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein

Stefan Arold*, Andreas S. Baur

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

The Nef protein of the human immunodeficiency virus is as important for disease progression as it is perplexing in its plethora of target molecules and functions. In this article, it is proposed that the complex biology of Nef is regulated through conformational changes of the protein that are triggered by cellular location and specific interactions as Nef traffics through the infected cell.

Original languageEnglish (US)
Pages (from-to)356-363
Number of pages8
JournalTrends in Biochemical Sciences
Volume26
Issue number6
DOIs
StatePublished - Jun 1 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein'. Together they form a unique fingerprint.

Cite this