Dynamic evolution of endogenous retrovirus-derived genes expressed in bovine conceptuses during the period of placentation

So Nakagawa, Hanako Bai, Toshihiro Sakurai, Yuki Nakaya, Toshihiro Konno, Takayuki Miyazawa, Takashi Gojobori, Kazuhiko Imakawa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

In evolution of mammals, some of essential genes for placental development are known to be of retroviralorigin, as syncytin-1 derived from an envelope (env) gene of an endogenous retrovirus (ERV) aids in the cell fusion of placenta in humans. Although the placenta serves the same function in all placental mammals, env-derived genes responsible for trophoblast cell fusion and maternal immune tolerance differ among species and remain largely unidentified in the bovine species. To examine env-derived genes playing a role in the bovine placental development comprehensively, we determined the transcriptomic profiles of bovine conceptuses during three crucial windows of implantation periods using a high-throughput sequencer. The sequence reads were mapped into the bovine genome, in which ERV candidates were annotated using RetroTector

Original languageEnglish (US)
Pages (from-to)296-306
Number of pages11
JournalGenome Biology and Evolution
Volume5
Issue number2
DOIs
StatePublished - Apr 29 2013

Keywords

  • Cow
  • Endogenous retrovirus
  • Envelope
  • RNA-seq
  • Syncytin

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics

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