Dual catalysis: A combined enantioselective brønsted acid and metal-catalyzed reaction - Metal catalysis with chiral counterions

Magnus Rueping*, Andrey P. Antonchick, Claus Brinkmann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

270 Scopus citations

Abstract

(Chemical Equation Presented) Double take: The combination of enantioselective Brønsted acid catalyzed activation and metal-catalyzed alkynylation of α-imino esters under mild reaction conditions leads to amino acids in high yields and with excellent e.r. values (see scheme; PG = protecting group).

Original languageEnglish (US)
Pages (from-to)6903-6906
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number36
DOIs
StatePublished - Sep 24 2007

Keywords

  • Alkynes
  • Asymmetric catalysis
  • Binol phosphate
  • Silver

ASJC Scopus subject areas

  • Chemistry(all)

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