Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles

Chenjie Xu, Keming Xu, Hongwei Gu, Rongkun Zheng, Hui Liu, Xixiang Zhang, Zhihong Guo, Bing Xu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

755 Scopus citations

Abstract

We report on the use of dopamine (DA) as a robust molecular anchor to link functional molecules to the iron oxide shell of magnetic nanoparticles. Using nitrilotriacetic acid (NTA) as the functional molecule, we created a system with an M/Fe2O3-DA-NTA (M = Co or SmCo5.2) nanostructure, which possesses high stability and specificity for separating histidine-tagged proteins. The well-established biocompatibility of iron oxide and the robust covalent bonds between DA and Fe2O3 render this strategy attractive for constructing biofunctional magnetic nanoparticles containing iron oxide.

Original languageEnglish (US)
Pages (from-to)9938-9939
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number32
DOIs
StatePublished - Aug 18 2004
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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