Does the intrinsic instability of aneuploid genomes have a causal role in cancer?

Marjori A. Matzke, Michael Mette, Tatsuo Kanno, Antonius J.M. Matzke

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

The role of aneuploidy in carcinogenesis has long been debated. We argue here that aneuploid genomes are naturally more susceptible to the types of chromosome rearrangement and epigenetic aberration that are found typically in tumor cells. In some cases, the formation of an aneuploid genome might be the initiating step in neoplastic conversion.

Original languageEnglish (US)
Pages (from-to)253-256
Number of pages4
JournalTrends in Genetics
Volume19
Issue number5
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Genetics

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