DNA sequence comparative analysis of the 3pter-p26 region of human genome

Chunqing Luo, Yan Li, Xiaowei Zhang, Yilin Zhang, Haiqing Zhang, Chong Chen, Zuyuan Xu, Peng Cui, Songnian Hu, Huanming Yang, Wei Dong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Most proterminal regions of human chromosomes are GC-rich and gene-rich. Chromosome 3p is an exception. Its proterminal region is GC-poor, and likely to lose heterozygosity, thus causing a number of fatal diseases. Except one gap left in the telomeric position, the proterminal region of human chromosome 3p has been completely sequenced. The detailed sequence analysis showed: (i) the GC content of this region was 38.5%, being the lowest among all the human proterminal regions; (ii) this region contained 20 known genes and 22 predicted genes, with an average gene size of 97.5 kb. The previously mapped gene Cntn3 was not found in this region, but instead located in the 74 Mb position of human chromosome 3p; (iii) the interspersed repeats of this region were more active than the average level of the whole human genome, especially (TA)n, the content of which was twice the genome average; (iv) this region had a conserved synteny extending from 104.1 Mb to 112.4 Mb on the mouse chromosome 6, which was 8% larger in size, not in accordance with the whole genome comparison, probably because the 3pter-p26 region was more likely to lose neocleitides and its mouse synteny had more active interspersed repeats. Copyright by Science in China Press 2005.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalScience in China, Series C: Life Sciences
Volume48
Issue number1
DOIs
StatePublished - Feb 1 2005

Keywords

  • 3pter-p26
  • Comparative analysis
  • Human genome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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