DNA Duplex Length and Salt Concentration Dependence of Enthalpy−Entropy Compensation Parameters for DNA Melting

E. B. Starikov, Bengt Nordén

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Systematical differential calorimetry experiments on DNA oligomers with different lengths and placed in water solutions with various added salt concentrations may, in principle, unravel important information about the structure and dynamics of the DNA and their water-counterion surrounding. With this in mind, to reinterpret the most recent results of calorimetric experiments on DNA oligomers of such a kind, the recent enthalpy-entropy compensation theory has been used. It is demonstrated that the application of the latter could enable direct estimation of thermodynamic parameters of the microphase transitions connected to the changes in DNA dynamical regimes versus the length of the biopolymers and the ionic strengths of their water solutions, and this calls for much more systematical experimental and theoretical studies in this field. © 2009 American Chemical Society.
Original languageEnglish (US)
Pages (from-to)11375-11377
Number of pages3
JournalThe Journal of Physical Chemistry B
Volume113
Issue number33
DOIs
StatePublished - Aug 20 2009
Externally publishedYes

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