Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells

Gustavo Tiscornia, Erica Lorenzo Vivas, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

142 Scopus citations

Abstract

The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs.

Original languageEnglish (US)
Pages (from-to)1570-1576
Number of pages7
JournalNature Medicine
Volume17
Issue number12
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells'. Together they form a unique fingerprint.

Cite this