Direct trifluoromethylthiolation of alcohols under mild reaction conditions: Conversion of R-OH into R-SCF 3

Pavlo Nikolaienko, Roman Pluta, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

A direct process for the trifluoromethylthiolation of allylic and benzylic alcohols under mild conditions has been developed. A wide range of free alcohols underwent nucleophilic substitution in the presence of stable CuSCF 3 and BF 3 ·Et 2 O to give the corresponding products in good to excellent yields.

Original languageEnglish (US)
Pages (from-to)9867-9870
Number of pages4
JournalChemistry - A European Journal
Volume20
Issue number32
DOIs
StatePublished - Aug 4 2014

Keywords

  • alcohols
  • nucleophilic substitution
  • thioethers
  • trifluoromethyl sulfenylation

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Direct trifluoromethylthiolation of alcohols under mild reaction conditions: Conversion of R-OH into R-SCF <sub>3</sub>'. Together they form a unique fingerprint.

Cite this