Direct catalytic benzylation of hydroxycoumarin - Efficient synthesis of warfarin derivatives and analogues

Magnus Rueping*, Boris J. Nachtsheim, Erli Sugiono

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Effective metal-catalyzed benzylations of 4-hydroxycoumarin have been developed. Employing a low amount of a cheap, nontoxic, and air-stable catalyst the 3-alkylated hydroxycoumarins were isolated in high yields after short reaction times. Applying this new methodology two widely used anticoagulants phenprocoumon and coumatetralyl were synthesized applying mild reaction conditions.

Original languageEnglish (US)
Pages (from-to)1549-1553
Number of pages5
JournalSynlett
Issue number10
DOIs
StatePublished - Jun 14 2010

Keywords

  • Benzylation
  • Bismuth
  • Green chemistry
  • Homogeneous catalysis
  • Hydroalkylation

ASJC Scopus subject areas

  • Organic Chemistry

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