Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy

Masashi Mizokami, Johnson Y.N. Lau*, Kaoru Suzuki, Tatsunori Nakano, Takashi Gojobori

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-α therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-α therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-α therapy. However, only group 3 remained after interferon-α therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-α.

Original languageEnglish (US)
Pages (from-to)884-886
Number of pages3
JournalJournal of Hepatology
Volume21
Issue number5
DOIs
StatePublished - Jan 1 1994

Keywords

  • Hepatitis C virus
  • Interferon-α
  • Molecular evolutionary analysis
  • Quasispecies
  • Selection

ASJC Scopus subject areas

  • Hepatology

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