Development of multiple stimuli responsive magnetic polymer nanocontainers as efficient drug delivery systems

Leto Aikaterini Tziveleka*, Panagiotis Bilalis, Alexandros Chatzipavlidis, Nikos Boukos, George Kordas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Magnetic nanodevices based on poly[(methacrylic acid)-co-(N- isopropylacrylamide)] [P(MAA-co-NIPAAm)] are prepared and used as drug delivery systems employing daunorubicin (DNR) as a model drug. The magnetic nanocontainers exploit the pH, temperature, and magnetic response of the polymeric shell constituents and magnetic nanoparticles, respectively, for controlled pH, temperature and alternating magnetic field triggered drug release. The in vitro cytotoxicity of both DNR-loaded and empty nanocontainers is examined on MCF-7 breast cancer cells along with the intracellular distribution of DNR. The results show that the DNR-loaded nanocontainers have an anti-tumor effect comparable to the free drug. The current observations provide important information for potent drug delivery and release systems.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalMacromolecular Bioscience
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • drug delivery systems
  • magnetic polymers
  • nanocontainers
  • pH response
  • temperature response

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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